Lopez Obrador is due to hold talks with US President Joe Biden and Canadian Prime Minister Justin Trudeau in Washington on Thursday at the first in-person meeting of the leaders of the three nations since 2016. Only Trudeau was in office last time.
"There are three issues: economic integration, migration and health regarding COVID and cooperation on dealing with the pandemic," Lopez Obrador told a regular news conference.
The Mexican president said labor mobility in the region would also be on the agenda, and reiterated that he did not intend to discuss a proposed electricity market reform in Mexico which has caused concern inside the US government.
Foreign Minister Marcelo Ebrard, Finance Minister Rogelio Ramirez de la O, Economy Minister Tatiana Clouthier, deputy health minister Hugo Lopez-Gatell and Mexico's migration chief would be in the Mexican delegation, Lopez Obrador added.
Lopez Obrador said he would travel on Wednesday to Washington and return early on Friday.
Later on Monday, Canada said its foreign minister, Melanie Joly, was flying to Mexico City for talks with Ebrard ahead of the Washington summit.
During the talks, Joly would highlight the importance of working together on North American competitiveness and shared challenges such as climate change, her government said.
