The Global Fund asked government, faith-based and private-sector partners to raise a total of US$13 billion at a donor conference in Montreal to support its activities over the next three years, starting in 2017.
The Global Fund, the world's largest aimed at fighting the three diseases, is credited with saving 20 million lives since it was established in 2002.
The United States, the fund's largest donor, in August pledged up to US$4.3 billion through 2019. The amount is subject to congressional approval.
The three diseases targeted by the fund are believed to kill more than 8,000 people a day.