The index closed 18.22 points lower after gaining 5.17 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 26% to 10.128 trillion VND (412.29 million USD).
The VN-30 basket, comprising the 30 largest capped stocks, saw 25 tickers fell.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 3.07% while the UPCoM-Index for the Unlisted Public Companies Market dropped 0.99%.