The index closed 4.94 points lower after gaining 10.46 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 52% to VND27.45 trillion ($101 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 14 tickers fell.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.77%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.79%.
