Transport Minister Dinh La Thang and Airbus Chief Executive Officer Tom Enders were among the few select passengers on board.
National flag carrier Vietnam Airlines ordered 10 A350 WWB aircraft from Airbus and will hire four others from the company. Once the first plane is delivered to Vietnam Airlines in mid-2015, it is due to fly the Hanoi-Paris route.
After flying across Seoul, Tokyo and Hanoi, A350 XWB will head into the skies of Bangkok and Kuala Lumpur next week before returning to Airbus headquarters in Toulouse.
With 750 orders from around the world already coming in, including 244 from Asia, the 369-seat aircraft is made of 53% of composite materials, allowing it to save fuel and fly 14,816km non-stop.
The aircraft seats four across in the 42-seat business class sections and nine across in the two economy cabins, offering all passengers entertainment boxes and bigger baggage compartments.