This is the first time the country's manufacturing output has fallen since last October when it decreased 0.4% year on year.
Excluding biomedical manufacturing, the output grew 9.4% year on year in September, compared to the revised 13.5% growth in August.
On a seasonally adjusted month-on-month basis, Singapore's manufacturing output dropped 2.8% in September. Excluding biomedical manufacturing, the output fell 5.1%.
In the first three quarters of this year, Singapore's manufacturing output grew 11.9% year on year. Excluding biomedical manufacturing, the output grew 14.8% year on year.