The rescue of a 2-year-old boy after 79 hours trapped in the rubble of a collapsed building in Hatay, Turkey, and several other people raised spirits among weary search crews. But hopes were fading that many more would be found alive in the ruins of towns and cities.
The death toll across both countries has now surpassed the more than 17,000 killed in 1999 when a similarly powerful earthquake hit northwest Turkey.
A Turkish official said the disaster posed "very serious difficulties" for the holding of an election scheduled for May 14.
In Syria's Idlib province, Munira Mohammad, a mother of four who fled Aleppo after the quake, said: "It is all children here, and we need heating and supplies. Last night we couldn't sleep because it was so cold. It is very bad."
Hundreds of thousands of people in both countries have been left homeless in the middle of winter. Many have camped out in makeshift shelters in supermarket car parks, mosques, roadsides or amid the ruins, often desperate for food, water and heat.
Some 40% of buildings in the Turkish city of Kahramanmaras, epicentre of the tremor, are damaged, according to a preliminary report by Turkey's Bogazici University.
ROADSIDE CAMPFIRES
At a gas station near the Turkish town of Kemalpasa, people picked through cardboard boxes of donated clothes. In the port city of Iskenderun, Reuters journalists saw people huddled round campfires on roadsides and in wrecked garages and warehouses.
Authorities say some 6,500 buildings in Turkey collapsed and countless more were damaged.
The death toll in Turkey rose to 17,406, Health Minister Fahrettin Koca said. In Syria, already devastated by nearly 12 years of civil war, more than 3,300 people have died, according to the government and a rescue service in the rebel-held northwest.
Turkish officials say some 13.5 million people were affected in an area spanning roughly 450 km (280 miles) from Adana in the west to Diyarbakir in the east. In Syria, people were killed as far south as Hama, 250 km from the epicentre.
Rescue crews looked for survivors at the site of a collapsed building in the dark in the city of Adiyaman with temperatures below freezing, Turkish broadcasters showed.
Teams frequently called for silence, asking all vehicles and generators to be turned off and reporters to keep quiet as they listened for sounds of anyone alive under the concrete blocks.
There were still some signs of hope.
A 2-year-old boy was picked out of the rubble by a Romanian and Polish rescue team in Hatay 79 hours after the earthquake, video released by Turkey's Humanitarian Relief Foundation (IHH) on Thursday showed.
The boy, wearing a blue, white and black striped sweater, cried as he was gently lifted from the hole where he had been trapped. He was carried away on a blanket. No other details were immediately available.
Another video from IHH showed a helmeted and dust-streaked rescuer weeping with emotion after successfully freeing a little girl from the rubble of a collapsed building in Kahramanmaras.
Greece sent thousands of tents, beds and blankets on Thursday to help those left homeless by the quake, in an act of solidarity with a neighbour that is a NATO ally but also a historic foe.
Israeli satellite intelligence was helping map the disaster zones in Turkey with mapping capabilities predominantly used for special operations, the Israeli military said.
SYRIA OVERWHELMED
In Syria, relief efforts are complicated by a conflict that has partitioned the country and wrecked its infrastructure.
The U.N. aid convoy entered Syria at the Bab Al Hawa crossing - a lifeline for accessing opposition-controlled areas where some 4 million people, many displaced by the war, were already relying on humanitarian aid.
U.N. Secretary-General Antonio Guterres pushed for more humanitarian access to northwestern Syria, saying he would be "very happy" if the United Nations could use more than one border crossing to deliver help.